The subject of the article is the functioning of the International Humanitarian City (IHC) as a global logistics hub in the humanitarian supply chain management (HSCM) in selected years. The justification for the selected issue is its importance in the context of responding to the humanitarian needs of the population mostly of Asia and Africa. Providing international humanitarian aid requires the provision of logistic solutions determining the development of HSCM. The research objective of this article is determining the role of the International Humanitarian City (IHC), a global logistics hub in the international humanitarian supply chain in 2018-2021. The research hypothesis is that the health, logistics and shelter were key sectors in the cluster approach represented in the IHC humanitarian activities in 2018-2021. The importance of IHC as an international logistics hub has grown due to high humanitarian needs of the population affected by the humanitarian crises of 2018-2021. Achieving the research goal and verifying the hypotheses was possible thanks to the use of research methods as case study, desk research (analysis of existing data), analysis of documents published by the IHC, as well as the method of critical analysis of scientific literature. The research concluded that the health, logistics and shelter sectors were the three key areas in humanitarian supply chain management, based on IHC activities. HSCM on the example of IHC was characterized by specialization in key areas of support for civilian populations. The specialization was typical of humanitarian logistics, corresponding to the cluster approach.